Coronary flow reserve in stress-echo lab. From pathophysiologic toy to diagnostic tool

The assessment of coronary flow reserve by transthoracic echocardiography has recently been introduced into clinical practice with gratifying results for the diagnosis of left anterior descending artery disease simultaneously reported by several independent laboratories. This technological novelty is changing the practice of stress echo for 3 main reasons. First, adding coronary flow reserve to regional wall motion allows us to have – in the same sitting – high specificity (regional wall motion) and a high sensitivity (coronary flow reserve) diagnostic marker, with an obvious improvement in overall diagnostic accuracy. Second, the technicalities of coronary flow reserve shift the balance of stress choice in favour of vasodilators, which are a more robust hyperemic stress and are substantially easier to perform with dual imaging than dobutamine or exercise. Third, the coronary flow reserve adds a quantitative support to the exquisitely qualitative assessment of wall motion analysis, thereby facilitating the communication of stress echo results to the cardiological world outside the echo lab. The next challenges involve the need to expand the exploration of coronary flow reserve to the right and circumflex coronary artery and to prove the additional prognostic value – if any – of coronary flow reserve over regional wall motion analysis, which remains the cornerstone of clinically-driven diagnosis in the stress echo lab

Characterizing the Coherence of Bose-Einstein Condensates and Atom Lasers

For a dilute, interacting Bose gas of magnetically-trapped atoms at temperatures below the critical temperature T 0 for Bose-Einstein condensation, we determine the second-order coherence function g (2)(r 1, r 2) within the framework of a finite-temperature quantum field theory. We show that, because of the different spatial distributions of condensate and thermal atoms in the trap, g (2)(r 1, r 2) does not depend on |r 1 - r 2| alone. This means that the experimental determinations of g (2) reported to date give only its spatial average. Such an average may underestimate the degree of coherence attainable in an atom laser by judicious engineering of the output coupler

Bogoliubov Approach to Superfluidity of Atoms in an Optical Lattice

We use the Bogoliubov theory of atoms in an optical lattice to study the approach to the Mott-insulator transition. We derive an explicit expression for the superfluid density based on the rigidity of the system under phase variations. This enables us to explore the connection between the quantum depletion of the condensate and the quasi-momentum distribution on the one hand and the superfluid fraction on the other. The approach to the insulator phase may be characterized through the filling of the band by quantum depletion, which should be directly observable via the matter–wave interference patterns. We complement these findings by self-consistent Hartree–Fock–Bogoliubov–Popov calculations for one-dimensional lattices, including the effects of a parabolic trapping potential

Infarct size and left ventricular remodelling after preventive percutaneous coronary intervention

Objective: We hypothesised that, compared with culprit-only primary percutaneous coronary intervention (PCI), additional preventive PCI in selected patients with ST-elevation myocardial infarction with multivessel disease would not be associated with iatrogenic myocardial infarction, and would be associated with reductions in left ventricular (LV) volumes in the longer term. Methods: In the preventive angioplasty in myocardial infarction trial (PRAMI; ISRCTN73028481), cardiac magnetic resonance (CMR) was prespecified in two centres and performed (median, IQR) 3 (1, 5) and 209 (189, 957) days after primary PCI. Results: From 219 enrolled patients in two sites, 84% underwent CMR. 42 (50%) were randomised to culprit-artery-only PCI and 42 (50%) were randomised to preventive PCI. Follow-up CMR scans were available in 72 (86%) patients. There were two (4.8%) cases of procedure-related myocardial infarction in the preventive PCI group. The culprit-artery-only group had a higher proportion of anterior myocardial infarctions (MIs) (55% vs 24%). Infarct sizes (% LV mass) at baseline and follow-up were similar. At follow-up, there was no difference in LV ejection fraction (%, median (IQR), (culprit-artery-only PCI vs preventive PCI) 51.7 (42.9, 60.2) vs 54.4 (49.3, 62.8), p=0.23), LV end-diastolic volume (mL/m2, 69.3 (59.4, 79.9) vs 66.1 (54.7, 73.7), p=0.48) and LV end-systolic volume (mL/m2, 31.8 (24.4, 43.0) vs 30.7 (23.0, 36.3), p=0.20). Non-culprit angiographic lesions had low-risk Syntax scores and 47% had non-complex characteristics. Conclusions: Compared with culprit-only PCI, non-infarct-artery MI in the preventive PCI strategy was uncommon and LV volumes and ejection fraction were similar

The High Time Resolution Universe Pulsar Survey I: System configuration and initial discoveries

We have embarked on a survey for pulsars and fast transients using the 13-beam Multibeam receiver on the Parkes radio telescope. Installation of a digital backend allows us to record 400 MHz of bandwidth for each beam, split into 1024 channels and sampled every 64 us. Limits of the receiver package restrict us to a 340 MHz observing band centred at 1352 MHz. The factor of eight improvement in frequency resolution over previous multibeam surveys allows us to probe deeper into the Galactic plane for short duration signals such as the pulses from millisecond pulsars. We plan to survey the entire southern sky in 42641 pointings, split into low, mid and high Galactic latitude regions, with integration times of 4200, 540 and 270 s respectively. Simulations suggest that we will discover 400 pulsars, of which 75 will be millisecond pulsars. With ~30% of the mid-latitude survey complete, we have re-detected 223 previously known pulsars and discovered 27 pulsars, 5 of which are millisecond pulsars. The newly discovered millisecond pulsars tend to have larger dispersion measures than those discovered in previous surveys, as expected from the improved time and frequency resolution of our instrument.Comment: Updated author list. 10 pages, 7 figures. For publication in MNRA

Visions, Values, and Videos: Revisiting Envisionings in Service of UbiComp Design for the Home

UbiComp has been envisioned to bring about a future dominated by calm computing technologies making our everyday lives ever more convenient. Yet the same vision has also attracted criticism for encouraging a solitary and passive lifestyle. The aim of this paper is to explore and elaborate these tensions further by examining the human values surrounding future domestic UbiComp solutions. Drawing on envisioning and contravisioning, we probe members of the public (N=28) through the presentation and focus group discussion of two contrasting animated video scenarios, where one is inspired by "calm" and the other by "engaging" visions of future UbiComp technology. By analysing the reasoning of our participants, we identify and elaborate a number of relevant values involved in balancing the two perspectives. In conclusion, we articulate practically applicable takeaways in the form of a set of key design questions and challenges.Comment: DIS'20, July 6-10, 2020, Eindhoven, Netherland

The High Time Resolution Universe Pulsar Survey IV: Discovery and polarimetry of millisecond pulsars

We present the discovery of six millisecond pulsars (MSPs) in the High Time Resolution Universe (HTRU) survey for pulsars and fast transients carried out with the Parkes radio telescope. All six are in binary systems with approximately circular orbits and are likely to have white dwarf companions. PSR J1017-7156 has a high flux density and a narrow pulse width, making it ideal for precision timing experiments. PSRs J1446-4701 and J1125-5825 are coincident with gamma-ray sources, and folding the high-energy photons with the radio timing ephemeris shows evidence of pulsed gamma-ray emission. PSR J1502-6752 has a spin period of 26.7 ms, and its low period derivative implies that it is a recycled pulsar. The orbital parameters indicate it has a very low mass function, and therefore a companion mass much lower than usually expected for such a mildly recycled pulsar. In addition we present polarisation profiles for all 12 MSPs discovered in the HTRU survey to date. Similar to previous observations of MSPs, we find that many have large widths and a wide range of linear and circular polarisation fractions. Their polarisation profiles can be highly complex, and although the observed position angles often do not obey the rotating vector model, we present several examples of those that do. We speculate that the emission heights of MSPs are a substantial fraction of the light cylinder radius in order to explain broad emission profiles, which then naturally leads to a large number of cases where emission from both poles is observed.Comment: Update to correct affiliation for CAASTRO. 16 pages, 18 figures. Accepted for publication in MNRA

The High Time Resolution Universe Survey VI: An Artificial Neural Network and Timing of 75 Pulsars

We present 75 pulsars discovered in the mid-latitude portion of the High Time Resolution Universe survey, 54 of which have full timing solutions. All the pulsars have spin periods greater than 100 ms, and none of those with timing solutions are in binaries. Two display particularly interesting behaviour; PSR J1054-5944 is found to be an intermittent pulsar, and PSR J1809-0119 has glitched twice since its discovery. In the second half of the paper we discuss the development and application of an artificial neural network in the data-processing pipeline for the survey. We discuss the tests that were used to generate scores and find that our neural network was able to reject over 99% of the candidates produced in the data processing, and able to blindly detect 85% of pulsars. We suggest that improvements to the accuracy should be possible if further care is taken when training an artificial neural network; for example ensuring that a representative sample of the pulsar population is used during the training process, or the use of different artificial neural networks for the detection of different types of pulsars.Comment: 15 pages, 8 figure

The High Time Resolution Universe Survey II: Discovery of 5 Millisecond Pulsars

We present the discovery of 5 millisecond pulsars found in the mid-Galactic latitude portion of the High Time Resolution Universe (HTRU) Survey. The pulsars have rotational periods from ~2.3 to ~7.5 ms, and all are in binary systems with orbital periods ranging from ~0.3 to ~150 d. In four of these systems, the most likely companion is a white dwarf, with minimum masses of ~0.2 Solar Masses. The other pulsar, J1731-1847, has a very low mass companion and exhibits eclipses, and is thus a member of the "black widow" class of pulsar binaries. These eclipses have been observed in bands centred near frequencies of 700, 1400 and 3000 MHz, from which measurements have been made of the electron density in the eclipse region. These measurements have been used to examine some possible eclipse mechanisms. The eclipse and other properties of this source are used to perform a comparison with the other known eclipsing and "black widow" pulsars. These new discoveries occupy a short-period and high-dispersion measure (DM) region of parameter space, which we demonstrate is a direct consequence of the high time and frequency resolution of the HTRU survey. The large implied distances to our new discoveries makes observation of their companions unlikely with both current optical telescopes and the Fermi Gamma-ray Space Telescope. The extremely circular orbits make any advance of periastron measurements highly unlikely. No relativistic Shapiro delays are obvious in any of the systems, although the low flux densities would make their detection difficult unless the orbits were fortuitously edge-on.Comment: 11 pages, 5 figures, 4 tables, for publication in MNRA

Holocene climate and environmental change in north-eastern Kamchatka (Russian Far East), inferred from a multi-proxy study of lake sediments

The study was supported by the Swedish Research Council through grants 621-2004-5224 and 621-2005-4444 to K.D. Bennett. A. Self and N. Solovieva acknowledge S. Brooks and V. Jones and were supported by NERC grant NE/H008160/1.A sediment record from a small lake in the north-eastern part of the Kamchatka Peninsula has been investigated in a multi-proxy study to gain knowledge of Holocene climatic and environmental change. Pollen, diatoms, chironomids and selected geochemical parameters were analysed and the sediment record was dated with radiocarbon. The study shows Holocene changes in the terrestrial vegetation as well as responses of the lake ecosystem to catchment maturity and multiple stressors, such as climate change and volcanic eruptions. Climate change is the major driving force resulting in the recorded environmental changes in the lake, although recurrent tephra deposition events also contributed. The sediment record has an age at the base of about 10,000 cal yrs BP, and during the first 400 years the climate was cold and the lake exhibited extensive ice-cover during winter and relatively low primary production. Soils in the catchment were poor with shrub alder and birches dominating the vegetation surrounding the lake. At about 9600–8900 cal yrs BP the climate was cold and moist, and strong seasonal wind stress resulted in reduced ice-cover and increased primary production. After ca. 8900 cal yrs BP the forest density increased around the lake, runoff decreased in a generally drier climate resulting in decreased primary production in the lake until ca. 7000 cal yrs BP. This generally dry climate was interrupted by a brief climatic perturbation, possibly attributed to the 8.2 ka event, indicating increasingly windy conditions with thick snow cover, reduced ice-cover and slightly elevated primary production in the lake. The diatom record shows maximum thermal stratification at ca. 6300–5800 cal yrs BP and indicates together with the geochemical proxies a dry and slightly warmer climate resulting in a high productive lake. The most remarkably change in the catchment vegetation occurred at ca. 4200 cal yrs BP in the form of a conspicuous increase in Siberian dwarf pine (Pinus pumila), indicating a shift to a cooler climate with a thicker and more long-lasting snow cover. This vegetational change was accompanied by marked shifts in the diatom and chironomid stratigraphies, which are also indicative of colder climate and more extensive ice-cover.Publisher PDFPeer reviewe